mTHPC--a drug on its way from second to third generation photosensitizer?
نویسنده
چکیده
5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan®) is now complemented by nanoformulations (Fospeg®, Foslip®) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs.
منابع مشابه
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عنوان ژورنال:
- Photodiagnosis and photodynamic therapy
دوره 9 2 شماره
صفحات -
تاریخ انتشار 2012